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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
1960 2
1962 1
1963 1
1964 1
1966 1
1967 1
1968 1
1970 3
1971 2
1973 3
1974 2
1975 13
1976 14
1977 6
1978 11
1979 10
1980 13
1981 21
1982 14
1983 11
1984 18
1985 19
1986 26
1987 15
1988 22
1989 22
1990 22
1991 22
1992 23
1993 29
1994 28
1995 31
1996 24
1997 31
1998 28
1999 29
2000 28
2001 37
2002 27
2003 32
2004 21
2005 25
2006 33
2007 38
2008 34
2009 31
2010 40
2011 41
2012 44
2013 30
2014 26
2015 30
2016 32
2017 37
2018 37
2019 34
2020 32
2021 53
2022 47
2023 55
2024 16

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1,287 results

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Page 1
Generation of ovarian follicles from mouse pluripotent stem cells.
Yoshino T, Suzuki T, Nagamatsu G, Yabukami H, Ikegaya M, Kishima M, Kita H, Imamura T, Nakashima K, Nishinakamura R, Tachibana M, Inoue M, Shima Y, Morohashi KI, Hayashi K. Yoshino T, et al. Science. 2021 Jul 16;373(6552):eabe0237. doi: 10.1126/science.abe0237. Science. 2021. PMID: 34437124
Oocytes mature in a specialized fluid-filled sac, the ovarian follicle, which provides signals needed for meiosis and germ cell growth. ...Generating functional mouse oocytes in a reconstituted ovarian environment provides a method for in vitro oocyte product …
Oocytes mature in a specialized fluid-filled sac, the ovarian follicle, which provides signals needed for meiosis and germ cel …
Hair-bearing human skin generated entirely from pluripotent stem cells.
Lee J, Rabbani CC, Gao H, Steinhart MR, Woodruff BM, Pflum ZE, Kim A, Heller S, Liu Y, Shipchandler TZ, Koehler KR. Lee J, et al. Nature. 2020 Jun;582(7812):399-404. doi: 10.1038/s41586-020-2352-3. Epub 2020 Jun 3. Nature. 2020. PMID: 32494013 Free PMC article.
We use stepwise modulation of the transforming growth factor beta (TGFbeta) and fibroblast growth factor (FGF) signalling pathways to co-induce cranial epithelial cells and neural crest cells within a spherical cell aggregate. During an incubation period of 4-5 months, we …
We use stepwise modulation of the transforming growth factor beta (TGFbeta) and fibroblast growth factor (FGF) signalling pathways to co-ind …
Biofabrication of Human Skin with Its Appendages.
Hosseini M, Koehler KR, Shafiee A. Hosseini M, et al. Adv Healthc Mater. 2022 Nov;11(22):e2201626. doi: 10.1002/adhm.202201626. Epub 2022 Sep 13. Adv Healthc Mater. 2022. PMID: 36063498 Review.
This review intends to provide an update on the recent efforts underway to regenerate appendage-bearing skin organs based on scaffold-free and scaffold-based bioengineering approaches. Although the mouse skin equivalents containing hair follicles, sebaceous glands, …
This review intends to provide an update on the recent efforts underway to regenerate appendage-bearing skin organs based on scaffold-free a …
Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction.
Kageyama T, Shimizu A, Anakama R, Nakajima R, Suzuki K, Okubo Y, Fukuda J. Kageyama T, et al. Sci Adv. 2022 Oct 21;8(42):eadd4603. doi: 10.1126/sciadv.add4603. Epub 2022 Oct 21. Sci Adv. 2022. PMID: 36269827 Free PMC article.
During embryonic development, reciprocal interactions between epidermal and mesenchymal layers trigger hair follicle morphogenesis. This study revealed that microenvironmental reprogramming via control over these interactions enabled hair follicle indu …
During embryonic development, reciprocal interactions between epidermal and mesenchymal layers trigger hair follicle morphogen …
Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases.
Ober-Reynolds B, Wang C, Ko JM, Rios EJ, Aasi SZ, Davis MM, Oro AE, Greenleaf WJ. Ober-Reynolds B, et al. Nat Genet. 2023 Aug;55(8):1288-1300. doi: 10.1038/s41588-023-01445-4. Epub 2023 Jul 27. Nat Genet. 2023. PMID: 37500727
Genome-wide association studies have identified many loci associated with hair and skin disease, but identification of causal variants requires deciphering of gene-regulatory networks in relevant cell types. We generated matched single-cell chromatin profiles and transcrip …
Genome-wide association studies have identified many loci associated with hair and skin disease, but identification of causal variant …
Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution.
Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. Cheng JB, et al. Cell Rep. 2018 Oct 23;25(4):871-883. doi: 10.1016/j.celrep.2018.09.006. Cell Rep. 2018. PMID: 30355494 Free PMC article.
Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression.
Pierson Smela MD, Kramme CC, Fortuna PRJ, Adams JL, Su R, Dong E, Kobayashi M, Brixi G, Kavirayuni VS, Tysinger E, Kohman RE, Shioda T, Chatterjee P, Church GM. Pierson Smela MD, et al. Elife. 2023 Feb 21;12:e83291. doi: 10.7554/eLife.83291. Elife. 2023. PMID: 36803359 Free PMC article.
An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. ...Our granulosa-like cells have transcriptomes similar to human fetal ovarian cells and recapitulate key ovarian phenotypes including follicle …
An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. ...Our granulosa-like cel …
Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice.
Hayashi K, Ogushi S, Kurimoto K, Shimamoto S, Ohta H, Saitou M. Hayashi K, et al. Science. 2012 Nov 16;338(6109):971-5. doi: 10.1126/science.1226889. Epub 2012 Oct 4. Science. 2012. PMID: 23042295
We show here that female (XX) embryonic stem cells and induced pluripotent stem cells in mice are induced into primordial germ cell-like cells (PGCLCs), which, when aggregated with female gonadal somatic cells as reconstituted ovaries, undergo X-reactivation, imprint erasu …
We show here that female (XX) embryonic stem cells and induced pluripotent stem cells in mice are induced into primordial germ cell-like cel …
Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair.
Ma L, Chen C, Liu D, Huang Z, Li J, Liu H, Kin Kwok RT, Tang B, Sui B, Zhang X, Tang J, Mao X, Huang W, Shi S, Kou X. Ma L, et al. Bioact Mater. 2022 May 11;19:626-641. doi: 10.1016/j.bioactmat.2022.04.022. eCollection 2023 Jan. Bioact Mater. 2022. PMID: 35600968 Free PMC article.
In this study, we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair follicles. Mechanistically, apoEVs activate the Wnt/beta-catenin pathway to facilitate their metabolism in a wave-like pattern. ...Furthermore, we show that …
In this study, we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair follicles. Mechan …
Mechanical force drives the initial mesenchymal-epithelial interaction during skin organoid development.
Wang M, Zhou X, Zhou S, Wang M, Jiang J, Wu W, Liu T, Xu W, Zhang J, Liu D, Zou Y, Qiu W, Zhang M, Liu W, Li Z, Wang D, Li T, Li J, Liu W, Yang L, Lei M. Wang M, et al. Theranostics. 2023 May 11;13(9):2930-2945. doi: 10.7150/thno.83217. eCollection 2023. Theranostics. 2023. PMID: 37284452 Free PMC article.
Here we used skin organoids as an example to study how mechanical force drives initial epidermal-dermal interaction which potentiates skin organoids to regenerate hair follicles. Methods: Live imaging analysis, single-cell RNA-sequencing analysis, and immunofluoresc …
Here we used skin organoids as an example to study how mechanical force drives initial epidermal-dermal interaction which potentiates skin o …
1,287 results